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Drosophila Protein Interaction Analysis

Protein interaction networks are composed of proteins that interact with each other to participate in various aspects of life processes such as biological signaling, gene expression regulation, energy and material metabolism, and cell cycle regulation. Systematic analysis of the interactions of a large number of proteins in biological systems is important for understanding the working principles of proteins in biological systems, understanding the response mechanisms of biological signaling and metabolism in special physiological states such as diseases, and understanding the functional connections between proteins.

CD BioSciences offers a total solution for Drosophila protein interaction network analysis. Our advanced platform includes biochemical analysis, high-density mass spectrometry, and comprehensive Drosophila protein interactions bioinformatics prediction and analysis. CD BioSciences provides attentive technical support and customized services to accelerate your projects.

Fig.1 Biological Implications of Protein Complexes (Guruharsha et al.2011)

What We Offer

Co-IP & GST pull-down - CD BioSciences offers a total solution for co-immunoprecipitation (Co-IP) and GST pull-down for Drosophila cell line samples and in vitro interaction studies with low technical difficulty and rapid and efficient detection of protein interactions. We have developed a well-established biochemical detection platform using protein-specific antibodies or fusion proteins with GST tags for in vitro detection.
High-throughput in vivo hybridization analysis of Drosophila - CD BioSciences has developed well-established systems for in vivo binary studies of Drosophila protein interactions, such as the Gal4-UAS and Q-system, which can be used to detect and validate physical interactions between proteins on a large scale. To reduce false positives in results, we recommend using multiple systems and screening strategies to query interactions between the same set of proteins.
Tandem mass spectrometry - Tandem mass spectrometry is a high-throughput, high-sensitivity instrument for the identification of protein interactions, which can detect peptides and complex subunits for quantitative, qualitative and structural analysis in a wide range of applications. CD BioSciences provides an advanced tandem LC-MS/MS platform for customers worldwide to identify interactions candidates obtained by affinity labeling (Strep, FLAG, MYC, etc.) and purification, combined with our Drosophila database for annotated classification of biological processes and molecular functions to speed up research.
Protein interaction database - CD BioSciences has many years of experience in Drosophila protein interaction research and has developed scalable protein interaction network database (e.g., tumor suppressor proteins, embryonic developmental proteins, intercellular signal exchange proteins, etc.) to help clients predict and identify unknown biological networks and gain insight into the processes by which proteins work together. We provide protein interaction network analysis, discovery of key proteins and sub-networks of complex networks, and functional clustering analysis of proteins (biological process, molecular function, cellular component, KEGG Pathway), etc.

General Workflow

Workflow of Drosophila Protein Interaction Analysis - CD BioSciences

Why Choose Us?

Rich experience in Drosophila protein interaction networks
Professional platforms guaranteeing the highest level of protein complexes identification
Automated sample processing to support large samples and reduce error
Fast turnaround, cost-effective and transparent pricing

CD BioSciences is an advanced sequencing and big data analysis biotechnology company. We are technology-oriented and provide total solution for Drosophila protein interaction network analysis. Our dedicated team provides high quality interpretation of analytical reports, including custom protein clustering analysis, biomarker identification and metabolic pathway association analysis. There are no limitations of our service. If you need any further information or have any question, please feel free to contact us.

References

Stanyon CA, et al. (2004). A Drosophila protein-interaction map centered on cell-cycle regulators. Genome biology. 5(12), 1-14.
Guruharsha KG, et al. (2011). A protein complex network of Drosophila melanogaster. Cell. 147(3), 690-703.
Belozerov VE, et al. (2012). High-resolution protein interaction map of the Drosophila melanogaster p38 mitogen-activated protein kinases reveals limited functional redundancy. Molecular and cellular biology. 32(18), 3695-3706.

For research use only. Not intended for any clinical use.

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