Drosophila Epigenetic Analysis Service
Epigenetics, heritable gene expression changes not altering DNA sequence, are mediated by chromatin structure or DNA methylation changes. Drosophila melanogaster, with its small size, short generation time, and genetic similarities to humans, is an ideal model for studying such biological phenomena. With a dedicated team of scientists and an advanced technology platform, CD BioSciences is committed to providing customers around the world with comprehensive solutions for exploring and understanding Drosophila epigenetics.
Introduction to Drosophila Epigenetics
Epigenetics in Drosophila involves studying how gene expression patterns in germ or somatic cells shape individual traits in offspring without modifying gene coding, particularly how a gene's genetic expression pattern, influenced by environmental factors, can be "remembered" and transmitted to the offspring. Within the realm of Drosophila, the focus of epigenetic analysis encompasses the investigation of heritable modifications in gene expression that operate independently of changes in DNA sequence. Predominantly, crucial epigenetic indicators like DNA methylation, histone alterations, and non-coding RNAs assume pivotal roles in the orchestration of diverse biological processes.
Fig.1 Epigenetic analysis of cyto-nuclear mismatch. (Grunau C., et al. 2018)
Scientists employ a variety of methods to delve into the realm of Drosophila epigenetics. Chromatin immunoprecipitation (ChIP) is a valuable technique for charting histone modifications and identifying binding sites of transcription factors across the genome. Through bisulfite sequencing, researchers can quantify patterns of DNA methylation. In parallel, tools for genetic manipulation, such as RNA interference (RNAi), come into play, aiding in the revelation of the functional significance held by distinct epigenetic regulators.
The investigation of epigenetic phenomena within Drosophila yields valuable insights into core inquiries of biology and the mechanics of diseases. Moreover, by unraveling the intricate epigenetic tapestry woven within these organisms, scientists cultivate a more profound comprehension of the orchestration of gene regulation.
Our Services
To reveal the complex interactions between genetic information and epigenetic modifications controlling gene expression, development, and inherited traits, CD BioSciences is committed to providing you with cutting-edge Drosophila epigenetic analysis services.
| Drosophila Epigenetic Analysis | Types of Modification |
|---|---|
| DNA Modification Analysis | Methylation: 5-methylcytosine (5-mC), 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC), N6-methyladenine (m6A), etc. |
| Acetylation: N-terminal acetylation, lysine acetylation, etc. | |
| Phosphorylation: O-phosphorylation, N-phosphorylation, S-phosphorylation, etc. | |
| Histone Modification Analysis | Methylation: 5-methylcytosine (5-mC), 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC), N6-methyladenine (m6A), etc. |
| Acetylation: N-terminal acetylation, lysine acetylation, etc. | |
| Phosphorylation: O-phosphorylation, N-phosphorylation, S-phosphorylation, etc. | |
| Ubiquitination: Mono-ubiquitination, multi-site mono-ubiquitination, polyubiquitinated chain, etc. | |
| Non-coding RNA Modification Analysis | ribosomal RNA (rRNA), transfer RNA (tRNA), small nuclear RNA (snRNA), etc. |
| RNA Modification Analysis | N6-methyladenine (m6A), N1-methyladenine (m1A), 5-hydroxymethylcytosine (hm5C), etc. |
| Chromatin Remodeling Modification Analysis | Chromatin Remodeling Factor: SWI (Switch) / SNF (Sucrose Nonfermenting), ISWI (Imitation Switch), CHD (Chromodomain Helicase DNA Binding Protein), INO80. |
Want to Learn More?
CD BioSciences specialize in unraveling the intricate epigenetic landscape of Drosophila, enabling groundbreaking insights into genetics, development, and beyond. Our dedicated and experienced team of experts is committed to providing you with comprehensive and tailored epigenetic analysis to move your research forward. Contact us to learn more about our service and discuss how we can assist you in your Drosophila research endeavors.
Reference
- Grunau C, Voigt S, Dobler R, et al. The cytoplasm affects the epigenome in Drosophila melanogaster. Epigenomes, 2018, 2(3): 17.
For research use only. Not intended for any clinical use.
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