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Human Disease Drosophila Model Service

Nearly 75% of human pathogenic genes are functionally homologous in Drosophila. Since 1918, when Drosophila models were used to study melanoma, most human genetic and degenerative diseases, such as tumors, neurodegenerative diseases, somnipathy, diabetes mellitus and obesity, have been studied using in vivo Drosophila models to investigate the molecular pathogenesis of disease. Compared with traditional mammalian models, Drosophila has unique advantages such as fast reproductive cycle, clear genetic background, simplicity and economy. We recommend the use of Drosophila models for in-depth basic research and drug discovery work on complex human diseases.

At CD BioSciences, our goal is to prepare clients with suitable Drosophila disease models to accelerate your scientific research. Relying on powerful genetic tools and platforms, we offer a total solution for Drosophila models targeting disease mutations in the human central nervous system, heart, liver and kidney.

Advantages and applications of Drosophila as a disease model Fig.1 Advantages and applications of Drosophila as a disease model (van der Voet et al. 2014)

General Strategy

Our high-quality Drosophila disease models can be used in a variety of research pipelines, including disease mechanism studies, target identification, drug discovery, and in vivo evaluation, etc. CD BioSciences is committed to saving our clients' costs and time. Our team consists of PhDs in Molecular Biology and Genetics, and strict QC ensures the genetic background and availability of Drosophila models, and we also offer other phenotypic testing services. At the end of the project, we provide you with complete assay data and a custom Drosophila model. CD BioSciences supports multiple strategies for building Drosophila disease models.

  • Drosophila mutants with specific phenotypes are screened by forward genetics strategies to identify endogenous genes that may cause disease. CD BioSciences has developed a series of platforms for unbiased disease phenotype screening in Drosophila to efficiently identify disease targets. Examples include neuropathy, obesity, and diabetes.
  • The function of disease-causing homologous genes in Drosophila can be studied through reverse genetics strategies to reveal the regulatory roles of these genes. CD BioSciences has developed genetic platforms based on genome-wide association studies that allow for extensive study of disease targets and mechanisms of disease onset. Examples include aging, sleep imbalance, and mendelian diseases.
  • CD BioSciences has developed genetic platforms based on genome-wide association studies that allow for extensive study of disease targets and mechanisms of disease onset. Examples include aging, sleep imbalance, and mendelian diseases.
  • We construct transgenic Drosophila models by directly transferring human disease-causing exogenous genes into the Drosophila genome while using a conditional control system to enable expression in specific tissues and cells. CD BioSciences supports strategies for gene knock-out, knock-in, knock-down and overexpressing to mimic diseases. For example, diseases with epigenetic characteristics such as tumors.
Strategy of Human Disease Drosophila Model

Why CD BioSciences?

  • Specialized genetically modifying platform – development of an expandable mutants pool of Drosophila, supporting CRISPR, transposons, recombinases and other genome modification technologies to provide optimal model building strategies.
  • Dedicated scientific team - one-to-one experiment design to ensure high-quality Drosophila disease models.
  • Flexible integral service - reliable data and visual analytics to meet our clients' project needs.
  • Fast and cost-effective supply - 7*24 service, close to customer's purpose, shorten customer's research time.

At CD BioSciences, our goal is to provide technology-driven bioscience services. Our project teams draw on years of research expertise to provide clients with high-quality, robust total solutions for Drosophila disease research models. At the end of the project, we send our clients with in vivo models and genetic validation reports, as well as construction strategies to accelerate your scientific research. Please feel free to contact us starting your private project customization.

References

  1. van der Voet M, et al. (2014). Drosophila models of early onset cognitive disorders and their clinical applications. Neuroscience & Biobehavioral Reviews. 46, 326-342.
  2. Ugur B, et al. (2016). Drosophila tools and assays for the study of human diseases. Disease models & mechanisms. 9(3), 235-244.

For research use only. Not intended for any clinical use.

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