Drosophila Models for Human Diseases
CD BioSciences has numerous genetically engineered Drosophila models that can be directly used for studies on gene functions, drug screening, and human diseases, thus effectively shortening your overall experimental cycle.
Our technical team has expertise in cell and molecular biology, single cell RNA seq, proteomics, and electrophysiology, providing clients with custom services speeding up researches and drug discoveries in various human diseases.
Our feature Drosophila models include but are not limited in:
- Alzheimer Disease
- Amyotrophic Lateral Sclerosis
- Cardiac Disease
- Diabetes and Obesity
- Huntington Disease
- Parkinson Disease
- Primary Ciliary Dyskinesia
- Cat. No (CDHDM-10006) Inquiry
- Relevant Diseases: Parkinson Disease
- Stock Symbol: PBac{PB}park[c00062]
- Target Gene(s): park
- Human Ortholog(s): PARK2
- Gene ID: 40336
- Genotype: w[1118]; PBac{w[+mC]=PB}park[c00062]/TM3, Sb[1] Ser[1]
- Description: Drosophila Parkin mutant (PB insertion into the 3rd intron).
- Cat. No (CDHDM-10008) Inquiry
- Relevant Diseases: Mitochondrial-Related Disorders
- Stock Symbol: PBac{PB}ND-MWFE[c00093]
- Target Gene(s): ND-MWFE
- Human Ortholog(s): NDUFA1
- Gene ID: 5740593
- Genotype: w[1118]; PBac{w[+mC]=PB}ND-MWFE[c00093]/CyO
- Description: This is a PBac{PB} insertion into an intron. It is uncharacterized but is an unverified lethal suggesting it may disrupt function.
- Cat. No (CDHDM-10017) Inquiry
- Relevant Diseases: Cardiac-Related Disease
- Stock Symbol: P{lacW}sls[j1D7]
- Target Gene(s): sls
- Human Ortholog(s): HMCN1
- Gene ID: 44013
- Genotype: y[1] w[*]; P{w[+mC]=lacW}sls[j1D7]/TM3, Sb[1]
- Description: P{lacW} insertion into coding sequence, causing disruptions at amino acid 471.
- Cat. No (CDHDM-10060) Inquiry
- Relevant Diseases: Muscular Dystrophy
- Stock Symbol: rt[P]
- Target Gene(s): rt
- Human Ortholog(s): POMT1
- Gene ID: 39297
- Genotype: mwh[1] P{hsneo}rt[P] red[1] e[1]/TM3, Sb[1] Ser[1]
- Description: rt mutant caused by insertion of a P{hsneo} transposon.
- Cat. No (CDHDM-10071) Inquiry
- Relevant Diseases: Seizure Disorders
- Stock Symbol: P{lacW}kdn[G0033]
- Target Gene(s): kdn
- Human Ortholog(s): CS
- Gene ID: 31579
- Genotype: w[67c23] P{w[+mC]=lacW}kdn[G0033]/FM7c
- Description: This insertion of a P{lacW} element (in the first or second intron depending on the transcript) is uncharacterized but is an unverified lethal (suggesting it may disrupt function), 8/16/2010.
- Cat. No (CDHDM-10108) Inquiry
- Relevant Diseases: Cardiac-Related Disease
- Stock Symbol: P{EP}sesB[EP319]
- Target Gene(s): sesB
- Human Ortholog(s): SLC25A4
- Gene ID: 32007
- Genotype: w[1118] P{w[+mC]=EP}sesB[EP319]
- Description: This P{EP} insertion just upstream of the transcription start is uncharacterized but is oriented correctly to overexpress all of sesB in the presence of GAL4. The insertion could also affect Ant2.
- Cat. No (CDHDM-10135) Inquiry
- Relevant Diseases: Seizure Disorders
- Stock Symbol: P{EP}eas[EP770]
- Target Gene(s): eas
- Human Ortholog(s): ETNK1
- Gene ID: 32585
- Genotype: w[1118] P{w[+mC]=EP}eas[EP770]
- Description: P{EP} insertion ~2.5 kb upstream of eas translation start. May overexpress eas in presence of GAL4 driver.
- Cat. No (CDHDM-1015) Inquiry
- Relevant Diseases: Metabolism/Diabetes/Obesity
- Stock Symbol: sws[olfE-x26]
- Target Gene(s): sws
- Human Ortholog(s): PNPLA6
- Gene ID: 31716
- Genotype: sws[olfE-x26]
- Description: sws null mtant.
- Cat. No (CDHDM-10177) Inquiry
- Relevant Diseases: Peroxisome Biogenesis Disorder
- Stock Symbol: P{lacW}Pex1[s4868]
- Target Gene(s): Pex1
- Human Ortholog(s): PEX1
- Gene ID: 45460
- Genotype: w[1118]; P{w[+mC]=lacW}Pex1[s4868]/TM3, P{ry[+t7.2]=ftz/lacC}SC1, ry[RK] Sb[1] Ser[1]
- Description: This P{lacW} is inserted into coding sequence in the 2nd exon. It results in reductions of transcript and protein levels and causes neuronal defects, developmental delay and other defects similar to those in human patients (see FBrf0215017).
For research use only. Not intended for any clinical use.