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Physiology and Metabolism Research Using Drosophila

CD BioSciences is a pioneer and practitioner in Drosophila research, and our goal is to use our knowledge of model organism Drosophila to advance scientific research in various fields such as Biology, Chemistry, Medicine, Environment, and Agriculture, etc. With our core technology and advanced platform, we hope to collaborate with research scholars around the world to use Drosophila as a breakthrough or starting point, helping achieve success in research projects.

Introduction

Metabolism is critical to understanding the phenotypic behavior of all organisms, including humans. In humans, metabolism is an integral part of health and has been associated with many diseases, e.g., obesity and diabetes, which becomes a key area of research in global public health. Fat accumulation or obesity is only one clinical manifestation of a disruption in the homeostatic balance of metabolism, moreover involves numerous complications collectively referred to as chronic metabolic diseases. Those diseases are often complex, involving several organs and systems, and developing slowly and imperceptibly. It has been found that most metabolic diseases are inherited congenital defects, but acquired diets, infections, etc. equally lead to both energy and substance metabolism disorders in the body. Therefore, conducting researches on metabolic regulation and physiopathological mechanisms is crucial to identify new targets, new metabolic pathways and networks, even comprehensive metabolic disease mechanisms.

The high level of genetic conservation between Drosophila melanogaster and mammals has helped convert many important knowledge into new discoveries and contribute to a better understanding of many biological processes in vertebrates. The Drosophila model has become a model organism for understanding the molecular mechanisms of metabolism and metabolic diseases over a century basic research. Insulin and adipokinetic hormone regulatory mechanisms similar to those regulated in humans have now been identified in Drosophila, which underscore the feasibility of Drosophila as a fundamental mechanism for studying metabolic imbalance syndromes.

Drosophila metabolic network and obesity-induced insulin resistance in humanFig.1 Drosophila metabolic network and obesity-induced insulin resistance in human (Padmanabha et al. 2014, Kolk BV 2018)

Extensive Metabolism and Pathological Research Experience

CD BioSciences has the ability to conduct comprehensive projects on metabolic homeostasis and physiological regulation in vivo through the Drosophila model. Our technical team collaborates with endocrinologists and metabolists to study the regulatory mechanisms of tissues, organs and systems, including humans. We have developed mutants resembling human metabolic disorders that can be used to study the involvement of lipid metabolism in visual development, mechanisms of diet-induced obesity, and mechanisms of anti-obesity drugs.

Drosophila is continuing to advance basic research on metabolic homeostasis and disease at an exciting pace, and our experience does not stop there.

  • Accurate manipulation and assessment of major conserved metabolic pathways and conserved phenotypes
  • The unprecedented ability to perform forward genetic screening with metabolic and behavioral endpoints
  • The inclusiveness of reverse genetics supports insights into the pathogenesis of inborn metabolic disorders
  • Thousands of loads provide the speed and cost-effectiveness of acquiring cross-species data

Related Services

CD BioSciences Drosophila center commitment to the development of basic biological sciences. We provide services including but not limited to:

Drosophila Lipid Metabolism
Drosophila Carbohydrates Metabolism
Drosophila Amino Acids Metabolism
Drosophila Metabolic Rate Detection  
Drosophila Stable Isotope Tracer Analysis

Our Advantages

  • Professionalism
    We have built a professional platform and team with rich experience and cutting-edge knowledge to guarantee the scientific direction of the project.
  • High Quality
    We focus on the quality of our products and services. Optimal fruit flies ensure project results.
  • Security
    We strictly fulfill the confidentiality agreement to protect the privacy of our clients.
  • Effective Price
    We insist on win-win situation, providing the most comprehensive and intimate services at the best price.

CD BioSciences is committed to advancing bioscience technology and basic research using Drosophila. With proven technologies and years of experience in the field of fruit fly, our PhD team conducts one-to-one technical consultancy and mechanistic studies to accelerate our clients' projects. Please feel free to contact us starting your private project customization.

References

  • Bharucha KN. (2009). The epicurean fly: using Drosophila melanogaster to study metabolism. Pediatric research, 65(2), 132-137.
  • Padmanabha D, et al. (2014). Drosophila gains traction as a repurposed tool to investigate metabolism. Trends in Endocrinology & Metabolism, 25(10), 518-527.
  • Kolk BV. (2018). Tissue-specific insulin resistance in human obesity: A physiological approach to lipid metabolism. Gildeprint Drukkerijen.
  • Musselman LP, et al. (2018). Drosophila as a model to study obesity and metabolic disease. Journal of Experimental Biology, 221(Suppl_1), jeb163881.

For research use only. Not intended for any clinical use.

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