Recombinant D. melanogaster Protein Z600(Z600)

Drosophila melanogaster

Z600

Z600; frs; CG17962; Protein Z600; Protein Fruhstart

1-90

Nucleus.

Cell cycle regulator that is involved in modulating and adjusting cell proliferation according to the requirements of the developmental program. Interacts with mitotic Cdk1-cyclin complexes to inhibit mitotic entry at the G2/M transition. Likely to function by binding to the hydrophobic patch of cyclins to interfere with the interaction between the complex and certain Cdk1 substrates. At the mid-blastula transition, involved in the cell cycle arrest in G2 of cycle 14 by delaying mitosis and thus reducing cell proliferation allowing cell fate specification and morphogenesis to take place. Acts downstream or in parallel to the checkpoint regulator grp which is also required for the cell cycle pause at cycle 14. During gastrulation, delays mitosis in the ventral region of the embryonic mesoderm thus allowing invagination to be completed before cell division takes place.

KEGG: Dmel_CG17962; STRING: 7227.FBpp0075304; UniGene: Dm.24004

Recombinant Protein

Yeast; E. coli; Baculovirus; Mammalian cell

MSSTNETNQV LQRLNSLKIV ETPKEQHEFG KRECYSLDSK KYSLVPATPS SSGHGKFQTE LKKRRKNKLN RMYTYEADKN FIKARKSLNF

Full Length Protein

>85% (SDS-PAGE)

The following tags are available. N-terminal His-tagged Tag-Free

Lyophilized powder

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Delivery time may differ from different purchasing ways or locations, please kindly consult us for specific delivery times.

Store at -20 °C/-80 °C upon receipt, aliquoting is necessary for multiple use.

The shelf life is related to many factors, including storage state, buffer ingredients, storage temperature, and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C.

Repeated freezing and thawing are not recommended.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Store working aliquots at 4 °C for up to one week.