Recombinant D. melanogaster Protein tailless(tll)

Drosophila melanogaster

tll

tll; NR2E2; CG1378; Protein tailless; Nuclear receptor subfamily 2 group E member 2

1-452

Nucleus.

Nuclear hormone receptor family, NR2 subfamily

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. This receptor binds to the consensus sequence [AG][AG]AAGTCAA. Plays a key role in the establishment of non-metameric domains at the anterior and posterior poles of the embryo. It may also play a role in the nervous system. The maternal terminal pathway activates the tll gene in the termini; TLL activity then represses segmentation and activates terminal-specific genes in these domains. Involved in the regulation of early eye development. In the embryonic visual system anlage drives cells to optic lobe as opposed to Bolwig's organ fate.

KEGG: Dmel_CG1378; STRING: 7227.FBpp0085071; UniGene: Dm.1906

Recombinant Protein

Yeast; E. coli; Baculovirus; Mammalian cell

MQSSEGSPDM MDQKYNSVRL SPAASSRILY HVPCKVCRDH SSGKHYGIYA CDGCAGFFKR SIRRSRQYVC KSQKQGLCVV DKTHRNQCRA CRLRKCFEVG MNKDAVQHER GPRNSTLRRH MAMYKDAMMG AGEMPQIPAE ILMNTAALTG FPGVPMPMPG LPQRAGHHPA HMAAFQPPPS AAAVLDLSVP RVPHHPVHQG HHGFFSPTAA YMNALATRAL PPTPPLMAAE HIKETAAEHL FKNVNWIKSV RAFTELPMPD QLLLLEESWK EFFILAMAQY LMPMNFAQLL FVYESENANR EIMGMVTREV HAFQEVLNQL CHLNIDSTEY ECLRAISLFR KSPPSASSTE DLANSSILTG SGSPNSSASA ESRGLLESGK VAAMHNDARS ALHNYIQRTH PSQPMRFQTL LGVVQLMHKV SSFTIEELFF RKTIGDITIV RLISDMYSQR KI

Full Length Protein

>85% (SDS-PAGE)

The following tags are available. N-terminal His-tagged Tag-Free

Lyophilized powder

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Delivery time may differ from different purchasing ways or locations, please kindly consult us for specific delivery times.

Store at -20 °C/-80 °C upon receipt, aliquoting is necessary for multiple use.

The shelf life is related to many factors, including storage state, buffer ingredients, storage temperature, and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C.

Repeated freezing and thawing are not recommended.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Store working aliquots at 4 °C for up to one week.