Recombinant D. melanogaster 12 kDa FK506-binding protein(FK506-bp2)

Species	Drosophila melanogaster
Target Names	FK506-bp2
Alternative Names	FK506-bp2; FKBP12; FKBP; EC 5.2.1.8; Macrolide-binding protein; Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase
Expression Region	1-108
Subcellular Location	Cytoplasm.
Protein Families	FKBP-type PPIase family, FKBP1 subfamily
Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Binds to ligand-free TGF beta type I receptor, from which it is released upon a ligand-induced, type II receptor mediated phosphorylation of the type I receptor. Binding is inhibitory to the signaling pathways of the TGF beta family ligands.
Database Info	KEGG: Dmel_CG11001; STRING: 7227.FBpp0085703; UniGene: Dm.2572

Product Type	Recombinant Protein
Source	Yeast; E. coli; Baculovirus; Mammalian cell
Target Protein Sequence	MGVQVVPIAP GDGSTYPKNG QKVTVHYTGT LDDGTKFDSS RDRNKPFKFT IGKGEVIRGW DEGVAQLSVG QRAKLICSPD YAYGSRGHPG VIPPNSTLTF DVELLKVE
Protein Length	Full Length Protein
Purity	>85% (SDS-PAGE)
Tag Info	The following tags are available. N-terminal His-tagged Tag-Free
Form	Lyophilized powder
Buffer before Lyophilization	Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Lead Time	Delivery time may differ from different purchasing ways or locations, please kindly consult us for specific delivery times.

Storage Condition	Store at -20 °C/-80 °C upon receipt, aliquoting is necessary for multiple use.
Shelf Life	The shelf life is related to many factors, including storage state, buffer ingredients, storage temperature, and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C.
Handling	Repeated freezing and thawing are not recommended.
Limitations	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Store working aliquots at 4 °C for up to one week.

For research use only. Not intended for any clinical use.