Anti-D. melanogaster Histone H4 [Dimethyl Lys20] Polyclonal Antibody - BSA Free

HIST4H4

When K20 is di-methylated on H4, the downstream effect is silencing of genes. This modification is also necessary and sufficient for 53BP1 binding, which is a prerequisite for DNA repair, a highly conserved mechanism. H4K20me2 is associated with hypoacetylation, and inactivation of certain genes. NSD1 and Suv420h1/2 trigger the dimethylation of K20, but only after SET8 catalyzes the mono-methylation of the same lysine, indicating a complex regulation of this modification that can so seriously affect replication and stability of genomic information.

Rabbit

Polyclonal

IgG

Non-conjugated

Immunogen affinity purified

Synthetic dimethylated peptide surrounding Lysine 20 of human Histone H4 [Swiss Prot P62805].

Liquid

PBS, 30% Glycerol

0.53 mg/mL

Made-to-order

WB, ChIP, DB, ICC/IF

Drosophila melanogaster

Store at -20 °C or -80 °C.

Avoid freeze-thaw cycles.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.